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KMID : 0892920170260060390
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Experimental Neurobiology
2017 Volume.26 No. 6 p.390 ~ p.398
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Maternal Separation Does Not Produce a Significant Behavioral Change in Mice
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Tan Shawn
Ho Hin San
Song Anna Yoon-Su
Low Joey
Je Hyun-Soo Shawn
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Abstract
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Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes. In this study, we sought to assess behavioral outcomes from two different early-life stress paradigms; a conventional 3-hour MS and a maternal separation with early weaning (MSEW) paradigm using C57BL/6J male mice with independent cohorts. Our data demonstrated that both MS and MSEW paradigms did not produce reported behavioral anomalies. Therefore, MS paradigms in mice require further validation and modification.
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KEYWORD
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Early-life stress, Maternal separation, Maternal separation with early weaning, Depression, Anxiety, Emotional memories
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